Workflows where traditional pipetting becomes the bottleneck: nanoliter dispensing, combinatorial condition screening, and repeatable plate-scale assembly — without tips.
Below is one published case study and other workflows that are a strong fit for droplet printing.
Droplet printing was used to assemble large combinatorial arrays of cell-free reactions in 384-well plates, enabling rapid exploration of artificial synthesis environments for membrane proteins.
Featured publication: The first droplet-printing platform was used to assemble high-throughput combinatorial reactions for membrane protein synthesis in a cell-free system (MEMPLEX).
The paper describes automated calibration, evaporation mitigation, and plate-scale combinatorial assembly using nanoliter droplets — making thousands of unique reaction compositions feasible and repeatable.
You don’t need a “droplet-specific” assay — you need a workflow where many conditions matter, reagents are expensive, or contamination risk and plastic waste are painful.
Shrink volumes to reduce costly reagents while maintaining precision — ideal for titrations and optimization.
Explore multivariate spaces and uncover interactions that one-factor-at-a-time experiments miss.
Make dense reaction matrices practical and iterate quickly on component mixes and conditions.
Map activity landscapes across substrates, inhibitors, cofactors, and buffers with minimal reagent per datapoint.
Reduce plastic usage and limit carryover — especially valuable when running many conditions per plate.
Tell us your assay and plate format. We’ll recommend a strong first validation experiment and estimate reagent savings and condition coverage.