Nanoliter liquid handling

High-throughput reaction assembly at the nanoliter scale

Print 10–25 nL droplets at 20 Hz with reagent-specific calibration and onboard imaging confirmation — designed by scientists for scientists.

10–25 nL
droplet volume
20 Hz
print frequency
<1%
typical CV
Up to 15
heads per experiment

Typical precision values depend on reagent properties and configuration; the system verifies droplet formation and volume during calibration before printing a plate.

LabCraft droplet printer with monitor showing the user interface
Automated calibration + guided experiment design — built into the workflow.

Why labs use droplet printing

Biology happens at microscopic scales — your liquid handling should too. By reducing reaction volumes, you can conserve expensive reagents, test more conditions, and move faster without sacrificing accuracy.

Spend less reagent

Miniaturize reactions to nanoliter dispenses so your most expensive components — like antibodies, enzymes, and cofactors — go dramatically farther.

Run more conditions

Explore larger experimental spaces: gradients, combinatorial designs, and screening matrices become practical when assembly is fast and low-volume.

Trust what you dispensed

Each reagent is calibrated before printing. Droplets are imaged on-board to confirm formation and quantify volume, so you can run with confidence.

Calibration result showing a droplet image and precision plots
Example calibration summary: droplet image plus precision metrics used to validate performance before printing.
Precision you can verify

Calibration + imaging before every print

Droplet formation can vary with viscosity, surface tension, and nozzle geometry. LabCraft calibrates each reagent and verifies droplets with an on-board microscope so the volume you intend is the volume you dispense.

  • Supports a wide range of biological reagents (from water to higher-viscosity mixtures)
  • Images multiple droplets to quantify precision and detect anomalies
  • Typical coefficient of variation across reagents is under 1%

From reagent to plate in minutes

A practical workflow built for real lab work: load a head, calibrate, then print into your plate at speed. Swap heads mid-run to increase capacity for complex multi-reagent experiments.

Machine picking up a printer head
Step 1

Pick up a printer head

Keep up to five heads loaded on the rack for fast switching, with the ability to swap heads during an experiment to reach up to fifteen total heads.

Printer head positioned in the on-board droplet imager
Step 2

Auto-calibrate + confirm droplets

The system calibrates droplet formation for each reagent and images droplets to confirm consistent volumes before you print a full plate.

Printer head suspended above a multiwell plate
Step 3

Print at high throughput

Dispense nanoliter droplets directly into well plates at 20 Hz for rapid experiment assembly — enabling large screens and dense condition coverage with minimal reagent usage.

Built for experimental design

Define the experiment you want — concentrations, combinations, replicates, and randomization — and the software computes stock solutions and droplet counts automatically. No spreadsheets. No scripting.

Non-contact dispensing

Reduce plastic waste and cross-contamination risk by eliminating tips.

Activity screening

Run more conditions per plate by assembling diverse mixes at nanoliter increments.

Assay miniaturization

Scale down reactions to reduce costs and increase experimental coverage.

Tell us your workflow — we’ll map it to a run plan

If you can describe the assay and the variables you care about, we can estimate the condition space you can cover and the reagent savings you can expect.